HRT - Combined

You may put an Evorel Sequi patch on at any time if:

• You have not used HRT before your menopause and no longer have menstrual periods

• Your menstrual cycles are not regular and you are not pregnant

• You are changing from HRT that does not give you a withdrawal bleed

Put an Evorel 50 patch on within 5 days of the start of bleeding if:

• You are not currently using HRT and still having regular periods

Put an Evorel 50 patch on at the end of a treatment cycle or one week after you finish using another HRT product if:

• You are changing from an HRT medicine that gives you a withdrawal bleed 10

If you are using another type of HRT:

• The day you start will depend on the type of HRT you have been using Talk to your doctor if you are not sure which type of HRT you are using.

Using the patches

The patches need to be changed twice a week. You must use the patches in the right order.

Weeks 1 and 2

Use the four Evorel 50 patches one at a time.

Weeks 3 and 4

Use the four Evorel Conti patches one at a time. As soon as you remove your fourth Evorel 50 patch, replace it with the first Evorel Conti patch. Start a new pack of Evorel Sequi as soon as you finish one. Do not leave a break between packs.

Changing your patches

• You must change the patches twice a week to give your body a steady supply of hormones. There is enough hormone in each patch to last for several days

• Change your patch on the same two days every week. This will mean that one patch is on for three days and the next patch for four days

• For example, if you apply your first patch on a Monday, change it on Thursday and again on the following Monday.

▪ Allergy to (hypersensitive) to conjugated oestrogens or any of the other ingredients of this medicine

▪ History of breast cancer

▪ Cancer which is sensitive to oestrogens such as cancer of the lining of the womb (endometrium) or if you are suspected of having it

▪ Any unexplained vaginal bleeding

▪ Excessive thickening of the womb lining (endometrial hyperplasia) that is not being treated

▪ History of a blood clot in a vein (thrombosis), such as in the legs (deep venous thrombosis) or the lungs (pulmonary embolism)

▪ A blood clotting disorder (such as protein C, protein S, or antithrombin deficiency)

▪ History of a disease caused by blood clots in the arteries, such as a heart attack, stroke or angina

▪ History of liver disease

▪ History of a rare blood problem called “porphyria” which is passed down in families (inherited)

▪ Pregnancy

• Breast-feeding

Very common (affects more than 1 in 10 people)

• Irritated, itchy, red skin and rash where the patch is applied

Common (affects less than 1 in 10 people)

• Feeling depressed or nervous

• Inappropriate signs of emotion

• Being unable to sleep

• Headache

• Itchy skin or red rash

• Feeling sick (nausea), or having stomach pain wind or other stomach upsets

• Diarrhea

• Pain including pain in the back, muscles, joints

• Breast pain

• Feeling generally unwell

• Weight gain

• Heavy vaginal bleeding, painful periods

• Water retention or build-up of fluid under the skin (oedema)

See other combined HRT products 

https://www.medicines.org.uk/emc/files/pil.10930.pdf